4Z1K

Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)

Summary for 4Z1K

Entry DOI	10.2210/pdb4z1k/pdb
Related	4Z0Q 4Z1E 4Z1J
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-[(6,7-dihydroxy-3,4-dihydroisoquinolin-2(1H)-yl)carbonyl]benzenesulfonamide, ... (4 entities in total)
Functional Keywords	lyase, carbonate dehydratase ii, carbonic anhydrase c, carbonic anhydrase ii, ca-ii, carbonate dehydratase ii- inhibitor complex
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29346.42
Authors	Brynda, J.,Pospisilova, K.,Rezacova, P.,Pachl, P. (deposition date: 2015-03-27, release date: 2015-08-26)
Primary citation	Buemi, M.R.,De Luca, L.,Ferro, S.,Bruno, E.,Ceruso, M.,Supuran, C.T.,Pospisilova, K.,Brynda, J.,Rezacova, P.,Gitto, R. Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms. Eur.J.Med.Chem., 102:223-232, 2015 Cited by PubMed: 26276436 DOI: 10.1016/j.ejmech.2015.07.049 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation