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4Z0K

Rapid development of two Factor IXa inhibitors from Hit to Lead

Summary for 4Z0K
Entry DOI10.2210/pdb4z0k/pdb
Related4YZU
DescriptorCoagulation factor IX, N-[(2R)-10-hydroxy-2,7-dimethyl-1,2,3,4-tetrahydropyrido[1,2-b]indazol-2-yl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ... (7 entities in total)
Functional Keywordsserine proteinase, blood coagulation, coagulation factor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
More
Cellular locationSecreted: P00740 P00740
Total number of polymer chains2
Total formula weight33614.69
Authors
Hruza, A.,Reichert, P. (deposition date: 2015-03-26, release date: 2015-05-20, Last modification date: 2023-09-27)
Primary citationParker, D.L.,Walsh, S.,Li, B.,Kim, E.,Sharipour, A.,Smith, C.,Chen, Y.H.,Berger, R.,Harper, B.,Zhang, T.,Park, M.,Shu, M.,Wu, J.,Xu, J.,Dewnani, S.,Sherer, E.C.,Hruza, A.,Reichert, P.,Geissler, W.,Sonatore, L.,Ellsworth, K.,Balkovec, J.,Greenlee, W.,Wood, H.B.
Rapid development of two factor IXa inhibitors from hit to lead.
Bioorg.Med.Chem.Lett., 25:2321-2325, 2015
Cited by
PubMed: 25937013
DOI: 10.1016/j.bmcl.2015.04.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.41 Å)
Structure validation

217705

数据于2024-03-27公开中

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