4YZU

Rapid development of two Factor IXa inhibitors from Hit to Lead

Summary for 4YZU

• Entry DOI: 10.2210/pdb4yzu/pdb
• Related: 4Z0K
• Descriptor: Coagulation factor IX, N-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-4-(4H-1,2,4-triazol-4-yl)benzamide, SODIUM ION, ... (7 entities in total)
• Functional Keywords: serine proteinase, blood coagulation, coagulation factor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted : P00740 P00740
• Total number of polymer chains: 2
• Total formula weight: 33572.66

Authors

Hruza, A.,Reichert, P. (deposition date: 2015-03-25, release date: 2015-05-20, Last modification date: 2023-09-27)

• Primary citation: Parker, D.L.,Walsh, S.,Li, B.,Kim, E.,Sharipour, A.,Smith, C.,Chen, Y.H.,Berger, R.,Harper, B.,Zhang, T.,Park, M.,Shu, M.,Wu, J.,Xu, J.,Dewnani, S.,Sherer, E.C.,Hruza, A.,Reichert, P.,Geissler, W.,Sonatore, L.,Ellsworth, K.,Balkovec, J.,Greenlee, W.,Wood, H.B.; Rapid development of two factor IXa inhibitors from hit to lead.; Bioorg.Med.Chem.Lett., 25:2321-2325, 2015; PubMed: 25937013; DOI: 10.1016/j.bmcl.2015.04.025

Experimental method

X-RAY DIFFRACTION (1.41 Å)