4YPQ

Crystal structure of the ROR(gamma)t ligand binding domain in complex with 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid

4YPQ の概要

• エントリーDOI: 10.2210/pdb4ypq/pdb
• 分子名称: Nuclear receptor ROR-gamma, 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: nuclear receptor ligand binding domain, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P51449
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28776.92

構造登録者

Leysen, S.,Scheepstra, M.,van Almen, G.C.,Ottmann, C.,Brunsveld, L. (登録日: 2015-03-13, 公開日: 2015-12-23, 最終更新日: 2024-01-10)

• 主引用文献: Scheepstra, M.,Leysen, S.,van Almen, G.C.,Miller, J.R.,Piesvaux, J.,Kutilek, V.,van Eenennaam, H.,Zhang, H.,Barr, K.,Nagpal, S.,Soisson, S.M.,Kornienko, M.,Wiley, K.,Elsen, N.,Sharma, S.,Correll, C.C.,Trotter, B.W.,van der Stelt, M.,Oubrie, A.,Ottmann, C.,Parthasarathy, G.,Brunsveld, L.; Identification of an allosteric binding site for ROR gamma t inhibition.; Nat Commun, 6:8833-8833, 2015; PubMed: 26640126; DOI: 10.1038/ncomms9833

実験手法

X-RAY DIFFRACTION (2.32 Å)