4YP8
Irak4-inhibitor co-structure
Summary for 4YP8
Entry DOI | 10.2210/pdb4yp8/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total) |
Functional Keywords | kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9NWZ3 |
Total number of polymer chains | 4 |
Total formula weight | 137775.07 |
Authors | Fischmann, T.O. (deposition date: 2015-03-12, release date: 2015-05-20, Last modification date: 2023-09-27) |
Primary citation | McElroy, W.T.,Tan, Z.,Ho, G.,Paliwal, S.,Li, G.,Seganish, W.M.,Tulshian, D.,Tata, J.,Fischmann, T.O.,Sondey, C.,Bian, H.,Bober, L.,Jackson, J.,Garlisi, C.G.,Devito, K.,Fossetta, J.,Lundell, D.,Niu, X. Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation. Acs Med.Chem.Lett., 6:677-682, 2015 Cited by PubMed: 26101573DOI: 10.1021/acsmedchemlett.5b00106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.641 Å) |
Structure validation
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