4YP8

Irak4-inhibitor co-structure

4YP8 の概要

• エントリーDOI: 10.2210/pdb4yp8/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
• 機能のキーワード: kinase, phosphatase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9NWZ3
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 137775.07

構造登録者

Fischmann, T.O. (登録日: 2015-03-12, 公開日: 2015-05-20, 最終更新日: 2023-09-27)

• 主引用文献: McElroy, W.T.,Tan, Z.,Ho, G.,Paliwal, S.,Li, G.,Seganish, W.M.,Tulshian, D.,Tata, J.,Fischmann, T.O.,Sondey, C.,Bian, H.,Bober, L.,Jackson, J.,Garlisi, C.G.,Devito, K.,Fossetta, J.,Lundell, D.,Niu, X.; Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.; Acs Med.Chem.Lett., 6:677-682, 2015; PubMed: 26101573; DOI: 10.1021/acsmedchemlett.5b00106

実験手法

X-RAY DIFFRACTION (2.641 Å)