4YMD

CL-K1 trimer bound to man(alpha1-2)man

Summary for 4YMD

• Entry DOI: 10.2210/pdb4ymd/pdb
• Related PRD ID: PRD_900111
• Descriptor: Collectin-11, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: c-type carbohydrate-recognition domain, collectin, c-type lectin, sugar binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : Q9BWP8
• Total number of polymer chains: 6
• Total formula weight: 106615.78

Authors

Wallis, R.,Venkatraman Girija, U.,Gingras, A.R.,Moody, P.C.E.,Marshall, J.E. (deposition date: 2015-03-06, release date: 2015-04-08, Last modification date: 2024-10-16)

Primary citation

Girija, U.V.,Furze, C.M.,Gingras, A.R.,Yoshizaki, T.,Ohtani, K.,Marshall, J.E.,Wallis, A.K.,Schwaeble, W.J.,El-Mezgueldi, M.,Mitchell, D.A.,Moody, P.C.,Wakamiya, N.,Wallis, R.
Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.
Bmc Biol., 13:27-27, 2015

PubMed Abstract: Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of complement and together with its associated serine protease MASP-3 serves as a guidance cue for neural crest development. High serum levels are associated with disseminated intravascular coagulation, where spontaneous clotting can lead to multiple organ failure. Autosomal mutations in the CL-K1 or MASP-3 genes cause a developmental disorder called 3MC (Carnevale, Mingarelli, Malpuech and Michels) syndrome, characterised by facial, genital, renal and limb abnormalities. One of these mutations (Gly(204)Ser in the CL-K1 gene) is associated with undetectable levels of protein in the serum of affected individuals.

PubMed: 25912189
DOI: 10.1186/s12915-015-0136-2

Experimental method

X-RAY DIFFRACTION (2.87 Å)