4YMD

CL-K1 trimer bound to man(alpha1-2)man

4YMD の概要

• エントリーDOI: 10.2210/pdb4ymd/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900111
• 分子名称: Collectin-11, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: c-type carbohydrate-recognition domain, collectin, c-type lectin, sugar binding protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Secreted : Q9BWP8
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 106615.78

構造登録者

Wallis, R.,Venkatraman Girija, U.,Gingras, A.R.,Moody, P.C.E.,Marshall, J.E. (登録日: 2015-03-06, 公開日: 2015-04-08, 最終更新日: 2024-10-16)

主引用文献

Girija, U.V.,Furze, C.M.,Gingras, A.R.,Yoshizaki, T.,Ohtani, K.,Marshall, J.E.,Wallis, A.K.,Schwaeble, W.J.,El-Mezgueldi, M.,Mitchell, D.A.,Moody, P.C.,Wakamiya, N.,Wallis, R.
Molecular basis of sugar recognition by collectin-K1 and the effects of mutations associated with 3MC syndrome.
Bmc Biol., 13:27-27, 2015

PubMed Abstract: Collectin-K1 (CL-K1, or CL-11) is a multifunctional Ca(2+)-dependent lectin with roles in innate immunity, apoptosis and embryogenesis. It binds to carbohydrates on pathogens to activate the lectin pathway of complement and together with its associated serine protease MASP-3 serves as a guidance cue for neural crest development. High serum levels are associated with disseminated intravascular coagulation, where spontaneous clotting can lead to multiple organ failure. Autosomal mutations in the CL-K1 or MASP-3 genes cause a developmental disorder called 3MC (Carnevale, Mingarelli, Malpuech and Michels) syndrome, characterised by facial, genital, renal and limb abnormalities. One of these mutations (Gly(204)Ser in the CL-K1 gene) is associated with undetectable levels of protein in the serum of affected individuals.

PubMed: 25912189
DOI: 10.1186/s12915-015-0136-2

実験手法

X-RAY DIFFRACTION (2.87 Å)