4YE3
Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 with Inhibitor GRL-4410A
Summary for 4YE3
| Entry DOI | 10.2210/pdb4ye3/pdb |
| Descriptor | Protease, YTTRIUM ION, CHLORIDE ION, ... (6 entities in total) |
| Functional Keywords | hiv-1 protease, drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Human immunodeficiency virus type 1 group M subtype B (HIV-1) |
| Total number of polymer chains | 2 |
| Total formula weight | 22842.86 |
| Authors | Agniswamy, J.,Weber, I.T. (deposition date: 2015-02-23, release date: 2015-06-10, Last modification date: 2023-09-27) |
| Primary citation | Agniswamy, J.,Louis, J.M.,Shen, C.H.,Yashchuk, S.,Ghosh, A.K.,Weber, I.T. Substituted Bis-THF Protease Inhibitors with Improved Potency against Highly Resistant Mature HIV-1 Protease PR20. J.Med.Chem., 58:5088-5095, 2015 Cited by PubMed: 26010498DOI: 10.1021/acs.jmedchem.5b00474 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
Download full validation report
