4YAT

Crystal structure of TRIM24 PHD-bromodomain complexed with N-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)-4-methoxybenzene-1-sulfonamide (5b)

4YAT の概要

• エントリーDOI: 10.2210/pdb4yat/pdb
• 関連するPDBエントリー: 4YAB 4YAD 4YAX 4YBM 4YBS 4YBT
• 分子名称: Transcription intermediary factor 1-alpha, ZINC ION, N-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-4-methoxybenzenesulfonamide, ... (4 entities in total)
• 機能のキーワード: center for biomolecular structure and function, bromodomain, trim24, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : O15164
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43593.20

構造登録者

Poncet-Montange, G.,Palmer, W.,Jones, P. (登録日: 2015-02-17, 公開日: 2015-06-24, 最終更新日: 2023-09-27)

• 主引用文献: Palmer, W.S.,Poncet-Montange, G.,Liu, G.,Petrocchi, A.,Reyna, N.,Subramanian, G.,Theroff, J.,Yau, A.,Kost-Alimova, M.,Bardenhagen, J.P.,Leo, E.,Shepard, H.E.,Tieu, T.N.,Shi, X.,Zhan, Y.,Zhao, S.,Barton, M.C.,Draetta, G.,Toniatti, C.,Jones, P.,Geck Do, M.,Andersen, J.N.; Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.; J.Med.Chem., 59:1440-1454, 2016; PubMed: 26061247; DOI: 10.1021/acs.jmedchem.5b00405

実験手法

X-RAY DIFFRACTION (2.18 Å)