4Y8S

Yeast 20S proteasome beta2-H116D mutant in complex with Ac-LAE-ep

Summary for 4Y8S

• Entry DOI: 10.2210/pdb4y8s/pdb
• Related: 1RYP
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, proteasome, mutant, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
• Biological source: Saccharomyces cerevisiae S288c (Baker's yeast); More
• Cellular location: Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451
• Total number of polymer chains: 34
• Total formula weight: 733878.26

Authors

Huber, E.M.,Groll, M. (deposition date: 2015-02-16, release date: 2015-06-17, Last modification date: 2024-01-10)

• Primary citation: Huber, E.M.,de Bruin, G.,Heinemeyer, W.,Paniagua Soriano, G.,Overkleeft, H.S.,Groll, M.; Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.; J.Am.Chem.Soc., 137:7835-7842, 2015; PubMed: 26020686; DOI: 10.1021/jacs.5b03688

Experimental method

X-RAY DIFFRACTION (2.7 Å)