4Y2G

Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide

4Y2G の概要

• エントリーDOI: 10.2210/pdb4y2g/pdb
• 分子名称: Breast cancer type 1 susceptibility protein, BRCA1-A complex subunit Abraxas (3 entities in total)
• 機能のキーワード: dna damage response, brct, phosphopeptide, ligase-peptide complex, antitumor protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398; Nucleus : Q6UWZ7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26734.58

構造登録者

Wu, Q.,Blundell, T.L. (登録日: 2015-02-09, 公開日: 2016-01-27, 最終更新日: 2024-05-01)

• 主引用文献: Wu, Q.,Paul, A.,Su, D.,Mehmood, S.,Foo, T.K.,Ochi, T.,Bunting, E.L.,Xia, B.,Robinson, C.V.,Wang, B.,Blundell, T.L.; Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.; Mol.Cell, 61:434-448, 2016; PubMed: 26778126; DOI: 10.1016/j.molcel.2015.12.017

実験手法

X-RAY DIFFRACTION (2.5 Å)