4Y2A

Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor

4Y2A の概要

• エントリーDOI: 10.2210/pdb4y2a/pdb
• 分子名称: 3D polymerase, 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), SULFATE ION, ... (5 entities in total)
• 機能のキーワード: polymerase, picornavirus, coxsackievirus, gpc-n114, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Coxsackievirus B3
• 細胞内の位置: Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03313
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54287.03

構造登録者

Vives-Adrian, L.,Ferrer-Orta, C.,Verdaguer, N. (登録日: 2015-02-09, 公開日: 2015-04-01, 最終更新日: 2024-01-10)

• 主引用文献: van der Linden, L.,Vives-Adrian, L.,Selisko, B.,Ferrer-Orta, C.,Liu, X.,Lanke, K.,Ulferts, R.,De Palma, A.M.,Tanchis, F.,Goris, N.,Lefebvre, D.,De Clercq, K.,Leyssen, P.,Lacroix, C.,Purstinger, G.,Coutard, B.,Canard, B.,Boehr, D.D.,Arnold, J.J.,Cameron, C.E.,Verdaguer, N.,Neyts, J.,van Kuppeveld, F.J.; The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.; Plos Pathog., 11:e1004733-e1004733, 2015; PubMed: 25799064; DOI: 10.1371/journal.ppat.1004733

実験手法

X-RAY DIFFRACTION (2.9 Å)