4XZM

Crystal structure of the methylated wild-type AKR1B10 holoenzyme

Summary for 4XZM

• Entry DOI: 10.2210/pdb4xzm/pdb
• Related: 1ZUA
• Descriptor: Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: tim barrel, aldo-keto reductase, oxidoreductase, holoenzyme, cytosolic
• Biological source: Homo sapiens (Human)
• Cellular location: Lysosome : O60218
• Total number of polymer chains: 1
• Total formula weight: 37223.57

Authors

Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Podjarny, A. (deposition date: 2015-02-04, release date: 2015-11-18, Last modification date: 2024-01-10)

• Primary citation: Ruiz, F.X.,Cousido-Siah, A.,Porte, S.,Dominguez, M.,Crespo, I.,Rechlin, C.,Mitschler, A.,de Lera, A.R.,Martin, M.J.,de la Fuente, J.A.,Klebe, G.,Pares, X.,Farres, J.,Podjarny, A.; Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10.; Chemmedchem, 10:1989-2003, 2015; PubMed: 26549844; DOI: 10.1002/cmdc.201500393

Experimental method

X-RAY DIFFRACTION (1.75 Å)