4XZ4

Structure of PI3K gamma in complex with an inhibitor

Summary for 4XZ4

• Entry DOI: 10.2210/pdb4xz4/pdb
• Related: 4XX5
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-[5-(6-methoxypyrazin-2-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide (3 entities in total)
• Functional Keywords: transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P48736
• Total number of polymer chains: 1
• Total formula weight: 111061.52

Authors

Collier, P.N.,Messersmith, D.,Le Tiran, A.,Bandarage, U.K.,Boucher, C.,Come, J.,Cottrell, K.M.,Damagnez, V.,Doran, J.D.,Griffith, J.P.,Khare-Pandit, S.,Krueger, E.B.,Ledeboer, M.W.,Ledford, B.,Liao, Y.,Mahajan, S.,Moody, C.S.,Wang, T.,Xu, J.,Aronov, A.M. (deposition date: 2015-02-03, release date: 2016-02-03, Last modification date: 2024-02-28)

• Primary citation: Collier, P.N.,Messersmith, D.,Le Tiran, A.,Bandarage, U.K.,Boucher, C.,Come, J.,Cottrell, K.M.,Damagnez, V.,Doran, J.D.,Griffith, J.P.,Khare-Pandit, S.,Krueger, E.B.,Ledeboer, M.W.,Ledford, B.,Liao, Y.,Mahajan, S.,Moody, C.S.,Wang, T.,Xu, J.,Aronov, A.M.; Structure of PI3K gamma in complex with an inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)