4XZ4

Structure of PI3K gamma in complex with an inhibitor

4XZ4 の概要

• エントリーDOI: 10.2210/pdb4xz4/pdb
• 関連するPDBエントリー: 4XX5
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N-[5-(6-methoxypyrazin-2-yl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl]acetamide (3 entities in total)
• 機能のキーワード: transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P48736
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111061.52

構造登録者

Collier, P.N.,Messersmith, D.,Le Tiran, A.,Bandarage, U.K.,Boucher, C.,Come, J.,Cottrell, K.M.,Damagnez, V.,Doran, J.D.,Griffith, J.P.,Khare-Pandit, S.,Krueger, E.B.,Ledeboer, M.W.,Ledford, B.,Liao, Y.,Mahajan, S.,Moody, C.S.,Wang, T.,Xu, J.,Aronov, A.M. (登録日: 2015-02-03, 公開日: 2016-02-03, 最終更新日: 2024-02-28)

• 主引用文献: Collier, P.N.,Messersmith, D.,Le Tiran, A.,Bandarage, U.K.,Boucher, C.,Come, J.,Cottrell, K.M.,Damagnez, V.,Doran, J.D.,Griffith, J.P.,Khare-Pandit, S.,Krueger, E.B.,Ledeboer, M.W.,Ledford, B.,Liao, Y.,Mahajan, S.,Moody, C.S.,Wang, T.,Xu, J.,Aronov, A.M.; Structure of PI3K gamma in complex with an inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (2.6 Å)