4XYA
Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand
Summary for 4XYA
Entry DOI | 10.2210/pdb4xya/pdb |
Descriptor | Bromodomain-containing protein 4, 6-(5-bromo-1-benzofuran-7-yl)-9H-purin-2-amine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, ligand, complex, structural genomics consortium, sgc, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15491.59 |
Authors | Picaud, S.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) (deposition date: 2015-02-02, release date: 2015-03-11, Last modification date: 2024-05-08) |
Primary citation | Picaud, S.,Strocchia, M.,Terracciano, S.,Lauro, G.,Mendez, J.,Daniels, D.L.,Riccio, R.,Bifulco, G.,Bruno, I.,Filippakopoulos, P. 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain. J.Med.Chem., 58:2718-2736, 2015 Cited by PubMed: 25703523DOI: 10.1021/jm501893k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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