4XY9

Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand

4XY9 の概要

• エントリーDOI: 10.2210/pdb4xy9/pdb
• 分子名称: Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 6-(5-bromo-2-methoxyphenyl)-9H-purin-2-amine, ... (4 entities in total)
• 機能のキーワード: bromodomain, complex, ligand, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O60885
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15481.59

構造登録者

Picaud, S.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Filippakopoulos, P.,Structural Genomics Consortium (SGC) (登録日: 2015-02-02, 公開日: 2015-03-11, 最終更新日: 2024-05-08)

• 主引用文献: Picaud, S.,Strocchia, M.,Terracciano, S.,Lauro, G.,Mendez, J.,Daniels, D.L.,Riccio, R.,Bifulco, G.,Bruno, I.,Filippakopoulos, P.; 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain.; J.Med.Chem., 58:2718-2736, 2015; PubMed: 25703523; DOI: 10.1021/jm501893k

実験手法

X-RAY DIFFRACTION (1.83 Å)