4XY2
Crystal structure of PDE10A in complex with ASP9436
Summary for 4XY2
Entry DOI | 10.2210/pdb4xy2/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 79817.77 |
Authors | Amano, Y.,Honbou, K. (deposition date: 2015-02-02, release date: 2015-06-17, Last modification date: 2024-03-20) |
Primary citation | Hamaguchi, W.,Masuda, N.,Miyamoto, S.,Kikuchi, S.,Narazaki, F.,Shiina, Y.,Seo, R.,Amano, Y.,Mihara, T.,Moriguchi, H.,Hattori, K. Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436 Bioorg.Med.Chem., 23:3351-3367, 2015 Cited by PubMed: 25960322DOI: 10.1016/j.bmc.2015.04.052 PDB entries with the same primary citation |
Experimental method |
Structure validation
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