4XXR

Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase

4XXR の概要

• エントリーDOI: 10.2210/pdb4xxr/pdb
• 分子名称: CTX-M-14 Class A Beta-Lactamase, POTASSIUM ION, [(1,2,3,4,5-eta)-1-(4-{[(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... (6 entities in total)
• 機能のキーワード: beta-lactamase organometallic ruthenocene ctx-m-14, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59106.29

構造登録者

Lewandowski, E.M.,Chen, Y. (登録日: 2015-01-30, 公開日: 2015-03-18, 最終更新日: 2023-09-27)

• 主引用文献: Lewandowski, E.M.,Skiba, J.,Torelli, N.J.,Rajnisz, A.,Solecka, J.,Kowalski, K.,Chen, Y.; Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated beta-lactam antibiotic.; Chem.Commun.(Camb.), 51:6186-6189, 2015; PubMed: 25753149; DOI: 10.1039/c5cc00904a

実験手法

X-RAY DIFFRACTION (1.18 Å)