4XVS

Crystal structure of HIV-1 donor 45 d45-01dG5 coreE gp120 with antibody 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 (VRC07_1995)

Summary for 4XVS

• Entry DOI: 10.2210/pdb4xvs/pdb
• Related: 4XVT
• Descriptor: VRC07_1995 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 Heavy chain, 45-VRC01.H01+07.O-863513/45-VRC01.L01+07.O-110653 Light chain, Donor 45 01dG5 coreE gp120, ... (5 entities in total)
• Functional Keywords: hiv-1 antibodyomics neutralizing antibody germline binding, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 91531.56

Authors

Joyce, M.G.,Mascola, J.R.,Kwong, P.D. (deposition date: 2015-01-27, release date: 2015-05-06, Last modification date: 2023-09-27)

• Primary citation: Wu, X.,Zhang, Z.,Schramm, C.A.,Joyce, M.G.,Do Kwon, Y.,Zhou, T.,Sheng, Z.,Zhang, B.,O'Dell, S.,McKee, K.,Georgiev, I.S.,Chuang, G.Y.,Longo, N.S.,Lynch, R.M.,Saunders, K.O.,Soto, C.,Srivatsan, S.,Yang, Y.,Bailer, R.T.,Louder, M.K.,Mullikin, J.C.,Connors, M.,Kwong, P.D.,Mascola, J.R.,Shapiro, L.; Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection.; Cell, 161:470-485, 2015; PubMed: 25865483; DOI: 10.1016/j.cell.2015.03.004

Experimental method

X-RAY DIFFRACTION (1.9 Å)