4XV3

B-Raf Kinase V600E oncogenic mutant in complex with PLX7922

Summary for 4XV3

• Entry DOI: 10.2210/pdb4xv3/pdb
• Related: 4K04 4K0I 4K1A
• Descriptor: Serine/threonine-protein kinase B-raf, N'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-N-ethyl-N-methylsulfuric diamide (3 entities in total)
• Functional Keywords: b-raf, braf, proto-oncogene, v600e, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 67050.85

Authors

Zhang, Y.,Zhang, C. (deposition date: 2015-01-26, release date: 2015-10-28, Last modification date: 2024-02-28)

• Primary citation: Zhang, C.,Spevak, W.,Zhang, Y.,Burton, E.A.,Ma, Y.,Habets, G.,Zhang, J.,Lin, J.,Ewing, T.,Matusow, B.,Tsang, G.,Marimuthu, A.,Cho, H.,Wu, G.,Wang, W.,Fong, D.,Nguyen, H.,Shi, S.,Womack, P.,Nespi, M.,Shellooe, R.,Carias, H.,Powell, B.,Light, E.,Sanftner, L.,Walters, J.,Tsai, J.,West, B.L.,Visor, G.,Rezaei, H.,Lin, P.S.,Nolop, K.,Ibrahim, P.N.,Hirth, P.,Bollag, G.; RAF inhibitors that evade paradoxical MAPK pathway activation.; Nature, 526:583-586, 2015; PubMed: 26466569; DOI: 10.1038/nature14982

Experimental method

X-RAY DIFFRACTION (2.8 Å)