4XUC
Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT): Structure with Cmpd18 (1-(biphenyl-3-yl)-3-hydroxypyridin-4(1H)-one)
4XUC の概要
エントリーDOI | 10.2210/pdb4xuc/pdb |
関連するPDBエントリー | 4XUD 4XUE |
分子名称 | Catechol O-methyltransferase, 1-(biphenyl-3-yl)-3-hydroxypyridin-4(1H)-one, MAGNESIUM ION, ... (6 entities in total) |
機能のキーワード | comt, catechol-o-methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side : P21964 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 25141.16 |
構造登録者 | Allison, T.,Wolkenberg, S.,Sanders, J.M.,Soisson, S.M. (登録日: 2015-01-25, 公開日: 2015-04-15, 最終更新日: 2024-02-28) |
主引用文献 | Harrison, S.T.,Poslusney, M.S.,Mulhearn, J.J.,Zhao, Z.,Kett, N.R.,Schubert, J.W.,Melamed, J.Y.,Allison, T.J.,Patel, S.B.,Sanders, J.M.,Sharma, S.,Smith, R.F.,Hall, D.L.,Robinson, R.G.,Sachs, N.A.,Hutson, P.H.,Wolkenberg, S.E.,Barrow, J.C. Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT). Acs Med.Chem.Lett., 6:318-323, 2015 Cited by PubMed: 25815153DOI: 10.1021/ml500502d 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
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