4XS3
Crystal structure of a metabolic reductase with (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one
Summary for 4XS3
Entry DOI | 10.2210/pdb4xs3/pdb |
Related | 4XRX |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, (E)-1-benzyl-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total) |
Functional Keywords | oxidoreductase/oxidoreductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 95539.93 |
Authors | |
Primary citation | Wu, F.,Jiang, H.,Zheng, B.,Kogiso, M.,Yao, Y.,Zhou, C.,Li, X.N.,Song, Y. Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J.Med.Chem., 58:6899-6908, 2015 Cited by PubMed: 26280302DOI: 10.1021/acs.jmedchem.5b00684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.291 Å) |
Structure validation
Download full validation report