4XRX

Crystal structure of a metabolic reductase with (E)-5-((1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl)pyridin-2(1H)-one

Summary for 4XRX

• Entry DOI: 10.2210/pdb4xrx/pdb
• Related: 4XS3
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(E)-(1-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)methyl]pyridin-2(1H)-one (3 entities in total)
• Functional Keywords: oxidoreductase/oxidoreductase inhibitor, oxidoreductase-oxidoreductase inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 95128.46

Authors

Zheng, B.,Wu, F.,Jiang, H.,Kogiso, M.,Yao, Y.,Zhou, C.,Li, X.,Song, Y. (deposition date: 2015-01-21, release date: 2015-12-09, Last modification date: 2024-02-28)

• Primary citation: Wu, F.,Jiang, H.,Zheng, B.,Kogiso, M.,Yao, Y.,Zhou, C.,Li, X.N.,Song, Y.; Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.; J.Med.Chem., 58:6899-6908, 2015; PubMed: 26280302; DOI: 10.1021/acs.jmedchem.5b00684

Experimental method

X-RAY DIFFRACTION (3.2 Å)