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4XJW

Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with DMSO as the cryoprotectant

Summary for 4XJW
Entry DOI10.2210/pdb4xjw/pdb
DescriptorSialidase B, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywordshydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts
Biological sourceStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Total number of polymer chains1
Total formula weight74220.74
Authors
Brear, P. (deposition date: 2015-01-09, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citationRogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J.
`The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB
To be published,
Experimental method
X-RAY DIFFRACTION (1.53 Å)
Structure validation

217705

數據於2024-03-27公開中

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