4XJU
Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid
4XJU の概要
エントリーDOI | 10.2210/pdb4xju/pdb |
分子名称 | Sialidase B, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... (5 entities in total) |
機能のキーワード | hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts |
由来する生物種 | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 74236.60 |
構造登録者 | |
主引用文献 | Rogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J. `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published, |
実験手法 | X-RAY DIFFRACTION (1.94 Å) |
構造検証レポート
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