4XJA
Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid
4XJA の概要
エントリーDOI | 10.2210/pdb4xja/pdb |
分子名称 | Sialidase B, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, PHOSPHATE ION, ... (6 entities in total) |
機能のキーワード | hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts |
由来する生物種 | Streptococcus pneumoniae TIGR4 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 74393.72 |
構造登録者 | |
主引用文献 | Rogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J. `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published, |
実験手法 | X-RAY DIFFRACTION (1.98 Å) |
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