4XIT

Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors

4XIT の概要

• エントリーDOI: 10.2210/pdb4xit/pdb
• 関連するPDBエントリー: 4XIP 4XIQ 4XIR
• 分子名称: Heat shock protein HSP 90-alpha, 2-chloro-5-(furan-2-ylmethyl)-8,11,11-trimethyl-9-oxo-6,7,9,10,11,12-hexahydro-5H-indolo[1,2-a][1,5]benzodiazepine-3-carboxamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26727.44

構造登録者

Zuccola, H.J.,Neubert, T. (登録日: 2015-01-07, 公開日: 2015-03-04, 最終更新日: 2024-02-28)

• 主引用文献: Neubert, T.,Numa, M.,Ernst, J.,Clemens, J.,Krenitsky, P.,Liu, M.,Fleck, B.,Woody, L.,Zuccola, H.,Stamos, D.; Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.; Bioorg.Med.Chem.Lett., 25:1338-1342, 2015; PubMed: 25677667; DOI: 10.1016/j.bmcl.2015.01.023

実験手法

X-RAY DIFFRACTION (1.86 Å)