4XIO

Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 8.0 with MPD as the cryoprotectant

4XIO の概要

• エントリーDOI: 10.2210/pdb4xio/pdb
• 分子名称: Sialidase B (2 entities in total)
• 機能のキーワード: hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts
• 由来する生物種: Streptococcus pneumoniae TIGR4
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 73519.85

構造登録者

Brear, P. (登録日: 2015-01-07, 公開日: 2016-01-20, 最終更新日: 2024-01-10)

• 主引用文献: Rogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J.; `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB; To be published,

実験手法

X-RAY DIFFRACTION (1.8 Å)