4XHX

Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin and 2-[(3-Chlorobenzyl)ammonio]ethanesulfonate

4XHX の概要

• エントリーDOI: 10.2210/pdb4xhx/pdb
• 分子名称: Sialidase B, 2-[(3-chlorobenzyl)amino]ethanesulfonic acid, (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, ... (5 entities in total)
• 機能のキーワード: hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts
• 由来する生物種: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 74297.35

構造登録者

Brear, P. (登録日: 2015-01-06, 公開日: 2016-01-20, 最終更新日: 2024-01-10)

• 主引用文献: Rogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J.; The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB; To be published,

実験手法

X-RAY DIFFRACTION (2.1 Å)