4XEW

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound

4XEW の概要

• エントリーDOI: 10.2210/pdb4xew/pdb
• 分子名称: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 6-(2-fluorophenyl)[1,3]dioxolo[4,5-g]quinolin-8(5H)-one, ... (4 entities in total)
• 機能のキーワード: inhibitor complex transaminase plp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98133.83

構造登録者

Finzel, B.C.,Dai, R. (登録日: 2014-12-25, 公開日: 2015-07-08, 最終更新日: 2023-09-27)

• 主引用文献: Dai, R.,Geders, T.W.,Liu, F.,Park, S.W.,Schnappinger, D.,Aldrich, C.C.,Finzel, B.C.; Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA.; J.Med.Chem., 58:5208-5217, 2015; PubMed: 26068403; DOI: 10.1021/acs.jmedchem.5b00092

実験手法

X-RAY DIFFRACTION (2.47 Å)