4X80

Crystal Structure of murine 7B4 Fab monoclonal antibody against ADAMTS5

4X80 の概要

• エントリーDOI: 10.2210/pdb4x80/pdb
• 関連するPDBエントリー: 4X8J
• 分子名称: IgG1 7B4 FAB Light Chain, IgG1 7B4 FAB Heavy chain (3 entities in total)
• 機能のキーワード: monoclonal, immune system
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 47693.81

構造登録者

Larkin, J.,Lohr, T.A.,Elefante, L.,Shearin, J.,Matico, R.,Su, J.-L.,Xue, Y.,Liu, F.,Genell, C.,Miller, R.E.,Tran, P.B.,Malfait, A.-M.,Maier, C.C.,Matheny, C.J. (登録日: 2014-12-09, 公開日: 2015-04-08, 最終更新日: 2015-08-05)

主引用文献

Larkin, J.,Lohr, T.A.,Elefante, L.,Shearin, J.,Matico, R.,Su, J.L.,Xue, Y.,Liu, F.,Genell, C.,Miller, R.E.,Tran, P.B.,Malfait, A.M.,Maier, C.C.,Matheny, C.J.
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Osteoarthr. Cartil., 23:1254-1266, 2015

PubMed Abstract: Aggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs) to both ADAMTS-5 and ADAMTS-4 were generated and in vitro, ex vivo and in vivo systems were utilized to assess target engagement, aggrecanase inhibition and modulation of disease-related endpoints with the intent of selecting a candidate for clinical development in osteoarthritis (OA).

PubMed: 25800415
DOI: 10.1016/j.joca.2015.02.778

実験手法

X-RAY DIFFRACTION (2.6 Å)