4X7N
Co-crystal Structure of PERK bound to 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one inhibitor
4X7N の概要
エントリーDOI | 10.2210/pdb4x7n/pdb |
関連するPDBエントリー | 4X7H 4X7J 4X7K 4X7L 4X7O |
分子名称 | Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3, 4-[2-amino-4-methyl-3-(2-methylquinolin-6-yl)benzoyl]-1-methyl-2,5-diphenyl-1,2-dihydro-3H-pyrazol-3-one, L(+)-TARTARIC ACID, ... (4 entities in total) |
機能のキーワード | catalytic domain, transferase-transferase inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) 詳細 |
細胞内の位置 | Endoplasmic reticulum membrane; Single-pass type I membrane protein: Q9NZJ5 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37491.06 |
構造登録者 | |
主引用文献 | Smith, A.L.,Andrews, K.L.,Beckmann, H.,Bellon, S.F.,Beltran, P.J.,Booker, S.,Chen, H.,Chung, Y.A.,D'Angelo, N.D.,Dao, J.,Dellamaggiore, K.R.,Jaeckel, P.,Kendall, R.,Labitzke, K.,Long, A.M.,Materna-Reichelt, S.,Mitchell, P.,Norman, M.H.,Powers, D.,Rose, M.,Shaffer, P.L.,Wu, M.M.,Lipford, J.R. Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK). J.Med.Chem., 58:1426-1441, 2015 Cited by PubMed: 25587754DOI: 10.1021/jm5017494 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.35 Å) |
構造検証レポート
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