4X6H

Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.

Summary for 4X6H

Entry DOI	10.2210/pdb4x6h/pdb
Descriptor	Cathepsin K, 4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, 4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide, ... (5 entities in total)
Functional Keywords	cathepsin k, inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	24738.57
Authors	Borisek, J.,Mohar, B.,Vizovisek, M.,Sosnowski, P.,Turk, D.,Turk, B.,Novic, M. (deposition date: 2014-12-08, release date: 2015-09-23, Last modification date: 2024-01-10)
Primary citation	Borisek, J.,Vizovisek, M.,Sosnowski, P.,Turk, B.,Turk, D.,Mohar, B.,Novic, M. Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58:6928-6937, 2015 Cited by PubMed: 26280490 DOI: 10.1021/acs.jmedchem.5b00746 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation