4X3R

Avi-GCPII structure in complex with FITC-conjugated GCPII-specific inhibitor

4X3R の概要

• エントリーDOI: 10.2210/pdb4x3r/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: glycoprotein, metallopeptidase, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 87653.81

構造登録者

Tykvart, J.,Konvalinka, J. (登録日: 2014-12-01, 公開日: 2015-10-14, 最終更新日: 2024-01-10)

• 主引用文献: Tykvart, J.,Schimer, J.,Jancarik, A.,Barinkova, J.,Navratil, V.,Starkova, J.,Sramkova, K.,Konvalinka, J.,Majer, P.,Sacha, P.; Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.; J.Med.Chem., 58:4357-4363, 2015; PubMed: 25923815; DOI: 10.1021/acs.jmedchem.5b00278

実験手法

X-RAY DIFFRACTION (1.86 Å)