4X3J

Selection of fragments for kinase inhibitor design: decoration is key

Summary for 4X3J

Entry DOI	10.2210/pdb4x3j/pdb
Descriptor	Angiopoietin-1 receptor, 1-[4-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea (3 entities in total)
Functional Keywords	transferase, protein kinase, inhibitor complex
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein: Q02763
Total number of polymer chains	1
Total formula weight	37252.40
Authors	Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-30, release date: 2014-12-24, Last modification date: 2024-05-08)
Primary citation	Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58:457-465, 2015 Cited by PubMed: 25437144 DOI: 10.1021/jm501597j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation