4X3J
Selection of fragments for kinase inhibitor design: decoration is key
Summary for 4X3J
Entry DOI | 10.2210/pdb4x3j/pdb |
Descriptor | Angiopoietin-1 receptor, 1-[4-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea (3 entities in total) |
Functional Keywords | transferase, protein kinase, inhibitor complex |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: Q02763 |
Total number of polymer chains | 1 |
Total formula weight | 37252.40 |
Authors | Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-30, release date: 2014-12-24, Last modification date: 2024-05-08) |
Primary citation | Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58:457-465, 2015 Cited by PubMed: 25437144DOI: 10.1021/jm501597j PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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