4X2J
Selection of fragments for kinase inhibitor design: decoration is key
Summary for 4X2J
| Entry DOI | 10.2210/pdb4x2j/pdb |
| Descriptor | TGF-beta receptor type-1, 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(8H)-one, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | transferase, protein kinase, inhibitor complex |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cell membrane; Single-pass type I membrane protein: P36897 |
| Total number of polymer chains | 1 |
| Total formula weight | 35231.47 |
| Authors | Czodrowski, P.,Hoelzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. (deposition date: 2014-11-26, release date: 2014-12-24, Last modification date: 2024-05-08) |
| Primary citation | Czodrowski, P.,Holzemann, G.,Barnickel, G.,Greiner, H.,Musil, D. Selection of fragments for kinase inhibitor design: decoration is key. J.Med.Chem., 58:457-465, 2015 Cited by PubMed: 25437144DOI: 10.1021/jm501597j PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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