4X1R

The crystal structure of mupain-1-12 in complex with murinised human uPA at pH7.4

Summary for 4X1R

• Entry DOI: 10.2210/pdb4x1r/pdb
• Related: 4N1P 4N1Q 4N1S 4X0W 4X1N
• Descriptor: mupain-1-12, Urokinase-type plasminogen activator, 1-phenylguanidine, ... (4 entities in total)
• Functional Keywords: serine protease, peptidic inhibitor, upa, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P00749
• Total number of polymer chains: 2
• Total formula weight: 29110.15

Authors

Jiang, L.,Zhao, B.,Xu, P.,Andreasen, P.,Huang, M. (deposition date: 2014-11-25, release date: 2015-03-25, Last modification date: 2023-11-08)

• Primary citation: Zhao, B.,Xu, P.,Jiang, L.,Paaske, B.,Kromann-Hansen, T.,Jensen, J.K.,Srensen, H.P.,Liu, Z.,Nielsen, J.T.,Christensen, A.,Hosseini, M.,Srensen, K.K.,Nielsen, N.C.,Jensen, K.J.,Huang, M.,Andreasen, P.A.; A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.; Plos One, 9:e115872-e115872, 2014; PubMed: 25545505; DOI: 10.1371/journal.pone.0115872

Experimental method

X-RAY DIFFRACTION (2.1 Å)