4WZ4

Crystal structure of P. aeruginosa AmpC

Summary for 4WZ4

• Entry DOI: 10.2210/pdb4wz4/pdb
• Related: 4WYY 4WZ5
• Descriptor: Beta-lactamase, GLYCEROL, {(3R)-6-[(3-amino-1,2,4-thiadiazol-5-yl)oxy]-1-hydroxy-4,5-dimethyl-1,3-dihydro-2,1-benzoxaborol-3-yl}acetic acid, ... (4 entities in total)
• Functional Keywords: beta lactamase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Pseudomonas aeruginosa PAO1
• Cellular location: Periplasm : P24735
• Total number of polymer chains: 1
• Total formula weight: 39926.77

Authors

Ferguson, A.D. (deposition date: 2014-11-18, release date: 2015-08-05, Last modification date: 2018-04-25)

• Primary citation: McKinney, D.C.,Zhou, F.,Eyermann, C.J.,Ferguson, A.D.,Prince, D.B.,Breen, J.,Giacobbe, R.A.,Lahiri, S.,Verheijen, J.C.; 4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine beta-Lactamase Inhibitors.; ACS Infect Dis, 1:310-316, 2015; PubMed: 27622821; DOI: 10.1021/acsinfecdis.5b00031

Experimental method

X-RAY DIFFRACTION (1.05 Å)