4WUY
Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor
Summary for 4WUY
Entry DOI | 10.2210/pdb4wuy/pdb |
Descriptor | N-lysine methyltransferase SMYD2, 5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide, S-ADENOSYL-L-HOMOCYSTEINE, ... (6 entities in total) |
Functional Keywords | smyd2 - lly-507, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : Q9NRG4 |
Total number of polymer chains | 1 |
Total formula weight | 52272.22 |
Authors | Nguyen, H.,Allali-Hassani, A.,Antonysamy, S.,Chang, S.,Chen, L.H.,Curtis, C.,Emtage, S.,Fan, L.,Gheyi, T.,Li, F.,Liu, S.,Martin, J.R.,Mendel, D.,Olsen, J.B.,Pelletier, L.,Shatseva, T.,Wu, S.,Zhang, F.F.,Arrowsmith, C.H.,Brown, P.J.,Campbell, R.M.,Garcia, B.A.,Barsyte-Lovejoy, D.,Mader, M.,Vedadi, M. (deposition date: 2014-11-04, release date: 2015-04-08, Last modification date: 2023-12-27) |
Primary citation | Nguyen, H.,Allali-Hassani, A.,Antonysamy, S.,Chang, S.,Chen, L.H.,Curtis, C.,Emtage, S.,Fan, L.,Gheyi, T.,Li, F.,Liu, S.,Martin, J.R.,Mendel, D.,Olsen, J.B.,Pelletier, L.,Shatseva, T.,Wu, S.,Zhang, F.F.,Arrowsmith, C.H.,Brown, P.J.,Campbell, R.M.,Garcia, B.A.,Barsyte-Lovejoy, D.,Mader, M.,Vedadi, M. LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J.Biol.Chem., 290:13641-13653, 2015 Cited by PubMed: 25825497DOI: 10.1074/jbc.M114.626861 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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