4WRS

Crystal structure of human Pim-1 kinase in complex with an azaspiro pyrazinyl-indazole inhibitor.

4WRS の概要

• エントリーDOI: 10.2210/pdb4wrs/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, GLYCEROL, 3-{6-[(4R)-6-azaspiro[2.5]oct-4-yloxy]pyrazin-2-yl}-5-(2,6-difluorophenyl)-1H-indazole, ... (4 entities in total)
• 機能のキーワード: transferase, serine/threonine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33682.06

構造登録者

Mohr, C. (登録日: 2014-10-25, 公開日: 2015-02-04, 最終更新日: 2023-12-27)

• 主引用文献: Wang, H.L.,Cee, V.J.,Chavez, F.,Lanman, B.A.,Reed, A.B.,Wu, B.,Guerrero, N.,Lipford, J.R.,Sastri, C.,Winston, J.,Andrews, K.L.,Huang, X.,Lee, M.R.,Mohr, C.,Xu, Y.,Zhou, Y.,Tasker, A.S.; The discovery of novel 3-(pyrazin-2-yl)-1H-indazoles as potent pan-Pim kinase inhibitors.; Bioorg.Med.Chem.Lett., 25:834-840, 2015; PubMed: 25597005; DOI: 10.1016/j.bmcl.2014.12.068

実験手法

X-RAY DIFFRACTION (2.2 Å)