4WRH

AKR1C3 complexed with breakdown product of N-(tert-butyl)-2-(2-chloro-4-(((3-mercapto-5-methyl-4H-1,2,4-triazol-4-yl)amino)methyl)-6-methoxyphenoxy)acetamide

4WRH の概要

• エントリーDOI: 10.2210/pdb4wrh/pdb
• 分子名称: Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[4-(aminomethyl)-2-chloro-6-methoxyphenoxy]-N-tert-butylacetamide, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, inhibitor, complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P42330
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39260.85

構造登録者

Squire, C.J.,Flanagan, J.U.,Yosaatmadja, Y. (登録日: 2014-10-24, 公開日: 2014-11-05, 最終更新日: 2023-09-27)

• 主引用文献: Yosaatmadja, Y.,Ko, R.-W.,Flanagan, J.U.,Squire, C.J.; Breakdown product of N-(tert-butyl)-2-(2-chloro-4-(((3-mercapto-5-methyl-4H-1,2,4-triazol-4-yl)amino)methyl)-6-methoxyphenoxy)acetamide trapped in active site of AKR1C3; To Be Published,

実験手法

X-RAY DIFFRACTION (1.6 Å)