4WKB

Crystal structure of Vibrio cholerae 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with methylthio-DADMe-Immucillin-A

4WKB の概要

• エントリーDOI: 10.2210/pdb4wkb/pdb
• 関連するPDBエントリー: 3DP9
• 分子名称: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, (3R,4S)-1-[(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)METHYL]-4-[(METHYLSULFANYL)METHYL]PYRROLIDIN-3-OL (3 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Vibrio cholerae serotype O1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53038.58

構造登録者

Cameron, S.A.,Thomas, K.,Almo, S.C.,Schramm, V.L. (登録日: 2014-10-02, 公開日: 2015-08-19, 最終更新日: 2023-09-27)

• 主引用文献: Thomas, K.,Cameron, S.A.,Almo, S.C.,Burgos, E.S.,Gulab, S.A.,Schramm, V.L.; Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.; Biochemistry, 54:2520-2529, 2015; PubMed: 25806409; DOI: 10.1021/bi501487w

実験手法

X-RAY DIFFRACTION (1.37 Å)