4WGI

A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)

4WGI の概要

• エントリーDOI: 10.2210/pdb4wgi/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, ... (6 entities in total)
• 機能のキーワード: fusion protein, mbp, transport protein, transport protein-inhibitor complex, apoptosis-inhibitor complex, apoptosis/inhibitor
• 由来する生物種: Escherichia coli O157:H7; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58804.38

構造登録者

Clifton, M.C.,Fairman, J.W.,Fang, C.,D'Souza, B.,Fulroth, B.,Leed, A.,McCarren, P.,Wang, L.,Wang, Y.,Kaushik, V.,Palmer, M.,Wei, G.,Golub, T.R.,Hubbard, B.K.,Serrano-Wu, M.H. (登録日: 2014-09-18, 公開日: 2014-11-19, 最終更新日: 2023-09-27)

• 主引用文献: Fang, C.,D'Souza, B.,Thompson, C.F.,Clifton, M.C.,Fairman, J.W.,Fulroth, B.,Leed, A.,McCarren, P.,Wang, L.,Wang, Y.,Feau, C.,Kaushik, V.K.,Palmer, M.,Wei, G.,Golub, T.R.,Hubbard, B.K.,Serrano-Wu, M.H.; Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).; Acs Med.Chem.Lett., 5:1308-1312, 2014; PubMed: 25516789; DOI: 10.1021/ml500388q

実験手法

X-RAY DIFFRACTION (1.85 Å)