4WGI
A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1)
4WGI の概要
エントリーDOI | 10.2210/pdb4wgi/pdb |
関連するBIRD辞書のPRD_ID | PRD_900001 |
分子名称 | Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, ... (6 entities in total) |
機能のキーワード | fusion protein, mbp, transport protein, transport protein-inhibitor complex, apoptosis-inhibitor complex, apoptosis/inhibitor |
由来する生物種 | Escherichia coli O157:H7 詳細 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 58804.38 |
構造登録者 | Clifton, M.C.,Fairman, J.W.,Fang, C.,D'Souza, B.,Fulroth, B.,Leed, A.,McCarren, P.,Wang, L.,Wang, Y.,Kaushik, V.,Palmer, M.,Wei, G.,Golub, T.R.,Hubbard, B.K.,Serrano-Wu, M.H. (登録日: 2014-09-18, 公開日: 2014-11-19, 最終更新日: 2023-09-27) |
主引用文献 | Fang, C.,D'Souza, B.,Thompson, C.F.,Clifton, M.C.,Fairman, J.W.,Fulroth, B.,Leed, A.,McCarren, P.,Wang, L.,Wang, Y.,Feau, C.,Kaushik, V.K.,Palmer, M.,Wei, G.,Golub, T.R.,Hubbard, B.K.,Serrano-Wu, M.H. Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1). Acs Med.Chem.Lett., 5:1308-1312, 2014 Cited by PubMed: 25516789DOI: 10.1021/ml500388q 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.85 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード