4WEV
Crystal structure of human AKR1B10 complexed with NADP+ and sulindac
Summary for 4WEV
Entry DOI | 10.2210/pdb4wev/pdb |
Related | 1ZUA |
Descriptor | Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, aldo-keto reductase, oxidoreductase, ari, carboxylic type, cytosolic |
Biological source | Homo sapiens (Human) |
Cellular location | Lysosome : O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37506.87 |
Authors | Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Crespo, I.,Porte, S.,Pares, X.,Farres, J.,Podjarny, A. (deposition date: 2014-09-11, release date: 2015-01-14, Last modification date: 2024-01-10) |
Primary citation | Cousido-Siah, A.,Ruiz, F.X.,Crespo, I.,Porte, S.,Mitschler, A.,Pares, X.,Podjarny, A.,Farres, J. Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10. Chem.Biol.Interact., 234:290-296, 2015 Cited by PubMed: 25532697DOI: 10.1016/j.cbi.2014.12.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.453 Å) |
Structure validation
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