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4WEV

Crystal structure of human AKR1B10 complexed with NADP+ and sulindac

Summary for 4WEV
Entry DOI10.2210/pdb4wev/pdb
Related1ZUA
DescriptorAldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1Z)-5-fluoro-2-methyl-1-{4-[methylsulfinyl]benzylidene}-1H-inden-3-yl]acetic acid, ... (4 entities in total)
Functional Keywordstim barrel, aldo-keto reductase, oxidoreductase, ari, carboxylic type, cytosolic
Biological sourceHomo sapiens (Human)
Cellular locationLysosome : O60218
Total number of polymer chains1
Total formula weight37506.87
Authors
Cousido-Siah, A.,Ruiz, F.X.,Mitschler, A.,Crespo, I.,Porte, S.,Pares, X.,Farres, J.,Podjarny, A. (deposition date: 2014-09-11, release date: 2015-01-14, Last modification date: 2024-01-10)
Primary citationCousido-Siah, A.,Ruiz, F.X.,Crespo, I.,Porte, S.,Mitschler, A.,Pares, X.,Podjarny, A.,Farres, J.
Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10.
Chem.Biol.Interact., 234:290-296, 2015
Cited by
PubMed: 25532697
DOI: 10.1016/j.cbi.2014.12.018
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.453 Å)
Structure validation

217705

数据于2024-03-27公开中

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