4WB7

Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A (catalytic alpha subunit)

Summary for 4WB7

Entry DOI	10.2210/pdb4wb7/pdb
Related	4WB5 4WB6 4WB8
Descriptor	DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, PKI (5-24), ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywords	chaperone, catalysis, protein kinase, adenosine triphosphate, phosphorylation, chimera, fusion, fibrolamellar hepatocellular carinoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm. Isoform 2: Cell projection, cilium, flagellum : P17612
Total number of polymer chains	4
Total formula weight	101632.21
Authors	Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Hendrickson, W.A. (deposition date: 2014-09-02, release date: 2015-01-21, Last modification date: 2023-09-27)
Primary citation	Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Robine, N.,Darnell, R.B.,Hendrickson, W.A. Structural insights into mis-regulation of protein kinase A in human tumors. Proc.Natl.Acad.Sci.USA, 112:1374-1379, 2015 Cited by PubMed: 25605907 DOI: 10.1073/pnas.1424206112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation