4WB7

Crystal structure of a chimeric fusion of human DnaJ (Hsp40) and cAMP-dependent protein kinase A (catalytic alpha subunit)

4WB7 の概要

• エントリーDOI: 10.2210/pdb4wb7/pdb
• 関連するPDBエントリー: 4WB5 4WB6 4WB8
• 分子名称: DnaJ homolog subfamily B member 1,cAMP-dependent protein kinase catalytic subunit alpha, PKI (5-24), ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: chaperone, catalysis, protein kinase, adenosine triphosphate, phosphorylation, chimera, fusion, fibrolamellar hepatocellular carinoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm. Isoform 2: Cell projection, cilium, flagellum : P17612
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101632.21

構造登録者

Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Hendrickson, W.A. (登録日: 2014-09-02, 公開日: 2015-01-21, 最終更新日: 2023-09-27)

• 主引用文献: Cheung, J.,Ginter, C.,Cassidy, M.,Franklin, M.C.,Rudolph, M.J.,Robine, N.,Darnell, R.B.,Hendrickson, W.A.; Structural insights into mis-regulation of protein kinase A in human tumors.; Proc.Natl.Acad.Sci.USA, 112:1374-1379, 2015; PubMed: 25605907; DOI: 10.1073/pnas.1424206112

実験手法

X-RAY DIFFRACTION (1.9 Å)