4WA3

The crystal structure of neuraminidase from a H3N8 influenza virus isolated from New England harbor seals

4WA3 の概要

• エントリーDOI: 10.2210/pdb4wa3/pdb
• 関連するPDBエントリー: 4WA1 4WA2 4WA4 4WA5
• 分子名称: Neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose, ... (6 entities in total)
• 機能のキーワード: neuraminidase, influenza virus, seal, viral protein
• 由来する生物種: Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))
• 細胞内の位置: Host apical cell membrane ; Single-pass type II membrane protein : I6NW33
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43420.47

構造登録者

Yang, H.,Villanueva, J.M.,Gubareva, L.V.,Stevens, J. (登録日: 2014-08-28, 公開日: 2015-01-14, 最終更新日: 2023-09-27)

主引用文献

Yang, H.,Nguyen, H.T.,Carney, P.J.,Guo, Z.,Chang, J.C.,Jones, J.,Davis, C.T.,Villanueva, J.M.,Gubareva, L.V.,Stevens, J.
Structural and Functional Analysis of Surface Proteins from an A(H3N8) Influenza Virus Isolated from New England Harbor Seals.
J.Virol., 89:2801-2812, 2015

PubMed Abstract: In late 2011, an A(H3N8) influenza virus infection resulted in the deaths of 162 New England harbor seals. Virus sequence analysis and virus receptor binding studies highlighted potential markers responsible for mammalian adaptation and a mixed receptor binding preference (S. J. Anthony, J. A. St Leger, K. Pugliares, H. S. Ip, J. M. Chan, Z. W. Carpenter, I. Navarrete-Macias, M. Sanchez-Leon, J. T. Saliki, J. Pedersen, W. Karesh, P. Daszak, R. Rabadan, T. Rowles, W. I. Lipkin, MBio 3:e00166-00112, 2012, http://dx.doi.org/10.1128/mBio.00166-12). Here, we present a detailed structural and biochemical analysis of the surface antigens of the virus. Results obtained with recombinant proteins for both the hemagglutinin and neuraminidase indicate a true avian receptor binding preference. Although the detection of this virus in new species highlights an increased potential for cross-species transmission, our results indicate that the A(H3N8) virus currently poses a low risk to humans.

PubMed: 25540377
DOI: 10.1128/JVI.02723-14

実験手法

X-RAY DIFFRACTION (1.801 Å)